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Home > Products >  Factory Supply USP/ EP 99% Letrozole ;Femara ;Letrozol powder

Factory Supply USP/ EP 99% Letrozole ;Femara ;Letrozol powder CAS NO.112809-51-5

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  • Min.Order: 1 Kilogram
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  • Product Details

Keywords

  • Femara powder
  • Letrozole powder
  • Letrozol powder

Quick Details

  • ProName: Factory Supply USP/ EP 99% Letrozole ;...
  • CasNo: 112809-51-5
  • Molecular Formula: C17H11N5
  • Appearance: powder
  • Application: pharmaceutical
  • DeliveryTime: In stock, at any time
  • PackAge: According client's requirements
  • Port: any chinese port
  • ProductionCapacity: 1 Metric Ton/Month
  • Purity: 99%
  • Storage: keep sealed and keep from direct light
  • Transportation: shipping by DHL,UPS,FEDEX,TNT,EMS,EUB…
  • LimitNum: 1 Kilogram

Superiority

 

[English Name] Letrozole
[Test Method]HPLC
[Purity]≥99%
[CAS No.] 112809-51-5
[Mol. Formula]C17H11N5
[Purity]> 99% by HPLC
[Packaging]1KG,25KG/DRUM...
Package and quantity according to customer's detail requirement
[Remark] In stock, customized for large scale.
 

Introduction:                              

1.CAS NO: 112809-51-5

2.letrozole Content: 99%

3.Molecular Formula: C17H11N5

4. Molecular Weight: 285.31

5. Appearance white or off-white powder

6. Melting point 181-183 ° C

7. Letrozole is an oral non-steroidal inhibitor for the treatment of hormonally-responsive breast cancer after surgery. letrozole prevents the aromatase from producing estrogens by competitive, reversible binding to the heme of its cytochrome p450 unit, the action is specific,and letrozol does not reduce production of mineralo-or corticosteroids.

Letrozole is a new generation aromatase inhibitor, is a synthetic derivative of benzyl triazole, letrozole by inhibiting aromatase, estrogen levels drop, thereby eliminating the stimulating effect of estrogen on tumor growth. Chemotherapy and radiotherapy for breast cancer.

Function:                                     

Letrozole is a new generation of highly selective aromatase inhibitors for synthetic benzyl triazole derivatives, by inhibiting aromatase, estrogen levels drop, thereby eliminating the stimulating effect of estrogen on tumor growth. In vivo activity than the first-generation aromatase inhibitor aminoglutethimide 150-250 times stronger. Due to its high selectivity, without affecting glucocorticoid mineralocorticoid and thyroid function, high doses of a corticosteroid like substances secreted without inhibition, and therefore it has a high therapeutic index. The pre-clinical studies have shown that letrozole for the whole body system and there is no potential target organ toxicity, no mutagenic and carcinogenic effects, and less side effects, well tolerated, and other aromatase inhibitors and anti- estrogen drugs compared to stronger anti-tumor effect. Suitable for patients with early breast cancer treatment as well as anti-estrogen therapy after treatment of advanced breast cancer in postmenopausal invalid.
December 2005 the British Medicines and Healthcare products regulatory approvals Novartis produced letrozole (Femara) is used to treat breast cancer patients, allowing it to be used after surgery, postmenopausal hormone-positive early invasive breast cancer patients. This is the second in June 2005 approved the British AstraZeneca Arimidex approved the first two aromatase inhibitors. Two drugs in clinical trials have shown that, compared with the current standard tamoxifen treatment can better prevent the risk of breast cancer recurrence.

Letrozole and anastrozole tablets distinguish letrozole tablets: for postmenopausal women with advanced breast cancer, second-line therapy for the treatment of multiple anti-estrogen therapy after failure.

Anastrozole: selective triazole aromatase inhibitors a potent, can inhibit the cytochrome P-450 aromatase enzyme depends thus blocking the biosynthesis of estrogens, and estrogen to stimulate breast cancer cells The main factor in the growth. The product of human placental aromatase 50% inhibitory concentration (IC50) is

15nmol / L.

Application:                                

1. Treatment of postmenopausal women with advanced breast cancer (estrogen receptor, progesterone receptor positive or unknown receptor status), used for anti-estrogen therapy after the failure of second-line treatment;

2. For locally advanced or spread after the first-line treatment of postmenopausal breast cancer (foreign data);

3. For the received standard adjuvant tamoxifen therapy in postmenopausal breast cancer after five years of adjuvant therapy in patients with extension (foreign data);

4. Postoperative adjuvant therapy for hormone-positive early breast cancer patients.

Specification:                           

Tests

Specifications

Results

Appearance

White or off-white crystaline powder

White

Crystalline powder

Solubility

 

Soluble in Chloroform;

Soluble in ethanol when heated

Conform

ldentification

(1)Maximum absorption in wavelength of 240 nm

Minimum absorption in wavelength of 215 nm

Conform

Conform

(2)Infrared spectrum should be in accordance the dominant peak of contrast

In accordance with the dominant peak of contrast

Melting points

182°C-184°C

182°C

Related substances

≤0.5%

0.3%

Single impurity

≤0.3%

0.2%

Loss on drying

≤1.0%

0.8%

[Assay]C17H11N5

(On anhydrous basis)

≥98.0%

99.2%

Conclusion

Conforms Specifications of Enterprise Standard.

Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers.

 

Our advantages:

 

1, High quality with competitive price:

1) Standard:BP/USP/EP/Enterprise standard

2) All Purity≥99%

3) We are manufacturer and can provide high quality products with factory price.

 

2, Fast and safe delivery

1) Parcel can be sent out in 24 hours after payment.Tracking number available

2) Secure and discreet shipment.Various transportation methods for your choice.

3) Customs pass rate ≥99%

4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, 

and we have stock in there for transferring.

 

3,We have clients throughout the world.

1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.

2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.

3) High quality,competitive price,fast delivery ,first-class service gain the trust and praise from the customers.

Details

Shaanxi Mingqi Chemical Co., Ltd is committed to the development of import and export trade in the production, operation and plant extracts of pharmaceutical raw materials and intermediates. It has trade with other Asian countries and Europe, the Americas and African countries. Important exporters of pharmaceutical chemical raw materials and the world's latest importers of pharmaceutical raw materials.

 

    Shaanxi Mingqi Chemical Co., Ltd has always been adhering to the company to market-oriented, customer-centric, with professional and enterprising team spirit and the company's strong financial strength, to provide customers with fast, high quality and efficient services, and always " To benefit customers "for the purpose.

 

      In the pharmaceutical raw materials and intermediates export business, the company by virtue of years of accumulated experience and high quality and reasonable talent structure, accurate grasp of the market, not only with a number of well-known domestic production enterprises to establish a long-term stable strategic cooperative relations in the global pharmaceutical chemical raw materials And chemical intermediates on the market also won the loyal customer base and a very strong strategic partner, set up a professional image of the outsourcing of pharmaceutical procurement. On the basis of continuing to develop the existing export trade business, the Company has formulated the idea of establishing independent research and development center and constructing the production base of pharmaceutical and chemical products according to the future development trend of the pharmaceutical and chemical industry, and strives to establish the combination of R & D, manufacturing and trade Of the business development model.

 

      While actively expanding their business and creating economic profits, enterprises do not forget their social responsibility, and actively participate in greening trees, poor students and other social activities, and become a tradition for many years, creating a good social benefits.

 

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